Methods Development

IMPACT (Transcription Factor Binding and Cell-Type-Specific Enhancer Prediction)

Amariuta, T., Luo, Y., Gazal, S., Davenport, E.E., van de Geijn, B., Ishigaki, K., Westra, H.J., Teslovich, N., Okada, Y., Yamamoto, K. and Price, A.L., 2019. IMPACT: genomic annotation of cell-state-specific regulatory elements inferred from the epigenome of bound transcription factors. The American Journal of Human Genetics (2019).

May 2, 2019

IMPACT 707 for Trans-Ancestry PRS

GitHub Paper

Amariuta, T., Ishigaki, K., Sugishita, H. et al. Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements. Nat Genet 52, 1346–1354 (2020).

November 30, 2020

TCSC: Tissue Co-regulation SCore Regression (Inferring Causal Cell Types in Disease)

GitHub Paper

Amariuta, T., Siewert-Rocks, K. & Price, A.L. Modeling tissue co-regulation estimates tissue-specific contributions to disease. Nat Genet 1503–1511 (2023).

August 14, 2023

MAGEPRO: Multi-Ancestry Gene Expression Prediction Regularized Optimization

GitHub Paper

Akamatsu, K., Golzari, S., Amariuta, T. Powerful mapping of cis-genetic effects on gene expression across diverse populations reveals novel disease-critical genes. medRxiv (2024).

September 26, 2024